I've loaded up the 80.5 Fullbore bullet for a custom .223 bolt rifle with a 26" barrel I had made as an F-TR practice rifle that was chambered with
zero freebore. Due to the [relatively] short barrel and reduction in effective case volume (the boattail/bearing surface junction of the 80.5 was seated well below the neck/shoulder junction), I chose to use H322 powder, which is a bit faster than I would ordinarily select for a .224" bullet of >80 gr weight. It is certainly not an ideal situation to have to load heavy bullets that way, but it can also certainly be done. That particular load shoots very well. That rifle also shoots FGMM 77 commercial ammo extremely well.
How much effort you have to put into the load development may well depend on exactly how much freebore you have. As noted, that particular rifle/chamber has zero freebore. If it had had even .025" to .050" freebore, it would have been helpful and made the process easier. In that event, I likely would have gone with H4895 instead of H322 with the 80.5s. Nonetheless, it is certainly possible to do what you're asking, but you will need to select a powder fast enough to achieve the approximate velocity range you're after, and that also has sufficiently low bulk density (i.e. small kernels) to fit a sufficient amount of it in the case, if the effective internal case volume is reduced by the bullet boattail/bearing surface as it was for me. If you play around with it a bit, you ought to be able to find a combination that will work. FWIW - in my specific case with the zero freebore setup, the resulting loaded rounds were still too long to reliably feed from most magazines (~COAL = 2.345"). That didn't matter to me as F-TR is single-feed anyhow, but still is worth mentioning.
Another issue you might run into has to do with caliper inserts. With bullets seated very deep in the neck and a caliper insert with a hole just under bullet diameter, you might just observe
extremely uniform seating depth, regardless of the seating die setting

. In fact, it wouldn't surprise me if you measured round after round and came up with a base-to-ogive measurement of
exactly 1.750". Ask me how I know this LOL. Turns out that with some bullets seated deep in the neck, the bullet ogive rifling contact point can actually be seated below the case mouth, such that a comparator insert with a hole very close to bullet diameter will actually seat on the case mouth, not the bullet ogive. Fortunately, it only took me about 8 or 10 loaded rounds to figure this out, whereupon I switched over to the Hornday comparator insert, which has a noticeably smaller hole and seat farther out on the bullet ogive.