Depending on brass capacity... I ran the #'s in Quickload with 50 gr total case H2O capacity, 22" barrel and with RL-16,,, 75 eldm, 2.650" COAL... it ended up at 66,777 psi. Which might sound like a lot, but some cartridges are rated to 65,000 psi.
6 and 6.5 CM are rated MAX psi around 61,000, probably cause of gas guns. I think it's still safe in a bolt gun, but definitely not in a gas gun, and no matter what, the brass will have short life span.
If I run the #'s in Quickload and RL-26,.. 22" bbl, 50 gr H20 capacity, the 22 creed will push the 75 eldm at 3,450 fps at 62,400 psi.
At least that's what the program estimates.