I did a considerable amount of bullet testing on coyotes about 20 years ago. I tried nosler tipped 55gr, I had never seen splash, but I did with those. 60gr sierra, exited unless you hit the shoulder bone on entry. 55gr Hornady spire points and 55gr winchester both had inconsistent results with some exits some not, but exits were 1.5". I am sure I tried some others as well, but don't recall. What I do recall is that once I tried a 55gr vmax, which I ran at 3050 fps, I never tried another bullet. Almost never an exit hole, only once on a 35 yard shot. Killed a couple hundred coyotes with the 55gr vmax, all the way out to 612 yards with most shot between 150 and 220 yards. I sold fur, I switched to a 17-223 because my fur buyer was complaining about 22 caliber entrance holes.
Broadside, quarter toward, straight on, or running away, those bullets worked well for me. Never a follow up shot unless I totally blew it and hit them in the back 1/3 of the body.