I haven't hunted prairie dogs since 1998, but if I were to go again, what should I use to shoot them? Back in the nineties I used .22 caliber rifles, with the .223 being my favorite. For longer shots, I normally used the .220 Swift. Most of the rifles were rebarreled Remington Model 700's with custom triggers (Jewell or Canjar). For scopes, I preferred the 6.5x-20X Leupold. I hunted SD, NE, CO, and WY (my favorite). I miss those days and wish I were young enough to try again. If I were to go today, I think I would use at least one 6mm; either a 6 PPC or 6 BR. What is your weapon(s) of choice? Good shooting.....James Ps-The above picture brings bitter sweet memories in that 2 of the 4 of us have since passed away. John Boughton (top) and Bucky Murdock in bottom picture with me.