I use a combo of a .223 bolt gun, A/R's in .223 and .20, a .17 Hornet, a .243 and a 6BR. They all are wonderful for respective ranges and conditions being shot - but if I were to use only one, I'd get a .223 if your range being shot is under 450 yards or a .243 if your range runs to and over that regularly. My Remington 700 .223 has more kills on it than the others combined. Using 50-grain Barnes Varmint Grenades and sometimes 70 TSX's. I don't save pelts. If I did, I'd not use the 70's, as very messy usually. The 50's usually only pass through if very short range.