I have not lost a coyote yet with the 17-223. I have had a couple of poorly placed shots that I followed up immediately with a second shot. I used to use a 223, I lost a few coyotes. On a poorly placed shot, I was reluctant to shoot again because with a spinning coyote you don't know what you're going to get and I didn't want another big hole in the hide. The hesitation on a follow up shot cost me a few. The 17 with its tiny entrance hole, I am not afraid of putting a second one it it. I have never had a "splash" with the 17. It also requires no vertical adjustment out to over 300 yards. 22-250 puts them down hard, but I think in marginal shots it does much more hide damage. More than a few coyotes were left unskinned with a 22-250 bullet that layed open the whole side, or the spine shot that left a softball sized hole in the back.